Tropical Sprue and Megaloblastic Anaemia

Erythrokinetics in the megaloblastic anemia of tropical sprue.

O NE OF the primary nlanifestations of tile clinical entity tropical sprue is a severe megaloblastic anemia. Although detailed descriptive information is available on tile blood and bone marrow morphology of this anenlia, its pathogenesis remains obscure.4’ The purpose of this report is to describe the quantitative aspects of red! cell production and dlestruction in this anemia. Our observation...

Aminoaciduria and megaloblastic anaemia.

Urinary amino-acid chromatograms from 23 patients with megaloblastic anaemia have been studied before and after therapy. The most consistent abnormality was an increased taurine or increased taurine/glycine ratio. This was not related directly to deficiency of vitamin B(12) or folic acid or to the degree of anaemia.

Tropical Sprue

Acidosis and severe megaloblastic anaemia.

Ten patients with severe megaloblastic anaemia were studied to investigate whether the causative metabolic defects might predispose them to lactic or other acidosis. One patient had compensated acidosis with hyperlactataemia before treatment but there were obvious causes other than anaemia. No other patient developed an acidosis. Neither anaemia per se nor the metabolic defects of vitamin B(12)...

Gout, Steatorrhoea, and Megaloblastic Anaemia.

Examination in Hospital.-He was febrile and pale with a smooth tongue. No splenic enlargement was detected. There were no significant neurological signs. The haemoglobin level was 33 per cent., red blood count 1,360,000/c.mm., colour index 1-27, average red cell diameter 7 8,t, and white blood count 5,800/c.mm. There was marked anisocytosis, poikilocytosis, scanty platelets, and 1 per cent. ret...